Allergic rhinitis is a common clinical entity affecting at least 10% of the population, and the incidence is increasing. Although many studies about the pathogenesis of allergic disease have been done, definite pathogenesis remained uncertain.
The
purpose of this study was to evaluate the distribution of immunohlobulin-bearing cell in nasal mucosa, and to compare the difference between aliergic and non-allergic rhinitis. We studied the thirty one histopathologic specimens of inferior
turbinate
mucosa from 17 allergic rhinitis and 14 non-allergic rhinitis from Oct. 1992 to Mar. 1993. The specimens were examined with hematoxylin-eosin staining and peroxidase-antipeoxidase immunohistologically
@ES The results were as follows:
@EN 1) the number of IgA-bearing cells in epithelial layer and stroma of allergic rhinitis group were significantly higher than non-allergic rhinitis group (P<0.05).
2) In glandular area, there was no statistically significant difference in the number of IgG-, IgA-, and IgM-bearing cells between allergic and non-allergic rhinitis.
3) In epithelial layer and stroma, there was no significant difference in the number of IgC-and IgM-bearing cells between allergic and non-allergic rhinitis.
4) In allergic rhinitis, IgG-bearing cells were predominantly infiltrated in glandular area histologically.
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